/* ============================================
   THE PEPTIDE WORLD — Page Styles
   Dark editorial, clinical mint accent, no medical-marketing aesthetic.
   ============================================ */

:root {
  --pep-bg:        #0E2520;
  --pep-bg-deep:   #081C18;
  --pep-t:         #7FE4C8;
  --pep-t-soft:    #A2EFD8;
  --pep-bd:        #3FA88C;
  --pep-bd-soft:   rgba(63, 168, 140, 0.36);
  --pep-bd-faint:  rgba(63, 168, 140, 0.16);
  --pep-glow:      rgba(127, 228, 200, 0.10);

  /* status accents */
  --pep-warn-t:    #F0B060;
  --pep-warn-bd:   rgba(240, 176, 96, 0.36);
  --pep-warn-bg:   rgba(240, 176, 96, 0.06);
  --pep-stop-t:    #F09070;
  --pep-stop-bd:   rgba(240, 144, 112, 0.42);
  --pep-stop-bg:   rgba(240, 144, 112, 0.06);
  --pep-info-t:    #6CB8E0;
  --pep-info-bd:   rgba(108, 184, 224, 0.36);
  --pep-info-bg:   rgba(108, 184, 224, 0.06);
  --pep-ok-t:      #98D89E;
  --pep-ok-bd:     rgba(152, 216, 158, 0.36);
  --pep-ok-bg:     rgba(152, 216, 158, 0.06);
}

/* ============================================
   HERO
   ============================================ */
.pep-hero { padding: 160px 0 60px; position: relative; }
.pep-hero-eyebrow {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px; font-weight: 600;
  letter-spacing: 0.18em; text-transform: uppercase;
  color: var(--pep-t); margin-bottom: 16px;
}
.pep-hero-title {
  font-size: clamp(36px, 6vw, 56px);
  font-weight: 700; line-height: 1.05;
  letter-spacing: -0.03em; color: var(--text);
  margin-bottom: 16px;
}
.pep-hero-title em { font-style: normal; color: var(--pep-t); }
.pep-hero-subtitle {
  font-size: 18px; font-weight: 400; line-height: 1.6;
  color: var(--text-secondary);
  max-width: 700px; margin-bottom: 24px;
}
.pep-hero-disclaimer {
  display: inline-flex; align-items: center; gap: 8px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px; letter-spacing: 0.12em;
  text-transform: uppercase; font-weight: 700;
  padding: 8px 14px; border-radius: 999px;
  background: var(--pep-warn-bg);
  border: 1px solid var(--pep-warn-bd);
  color: var(--pep-warn-t);
  margin-bottom: 28px;
}
.pep-hero-disclaimer::before {
  content: '⚠'; font-size: 13px; line-height: 1;
}

/* Hero stats */
.pep-hero-stats {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
  gap: 12px; max-width: 880px;
}
.pep-hero-stat {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-left: 2px solid var(--pep-bd-soft);
  border-radius: 10px;
  padding: 14px 16px;
}
.pep-hero-stat-num {
  font-family: 'JetBrains Mono', monospace;
  font-size: 18px; font-weight: 700;
  color: var(--pep-t);
  font-variant-numeric: tabular-nums;
  margin-bottom: 3px;
  line-height: 1.2;
}
.pep-hero-stat-label {
  font-size: 12px;
  color: var(--text-tertiary);
  line-height: 1.5;
}

/* ============================================
   STICKY ToC (desktop)
   ============================================ */
.pep-layout {
  display: grid;
  grid-template-columns: 1fr;
  gap: 0;
}
.pep-toc {
  display: none;
}
@media (min-width: 1100px) {
  .pep-layout {
    grid-template-columns: minmax(0, 1fr) 220px;
    gap: 40px;
  }
  .pep-toc {
    display: block;
    position: sticky;
    top: 90px;
    align-self: start;
    border-left: 1px solid var(--border-light);
    padding-left: 18px;
    max-height: calc(100vh - 110px);
    overflow-y: auto;
  }
}
.pep-toc-h {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10.5px; letter-spacing: 0.16em;
  text-transform: uppercase; font-weight: 700;
  color: var(--pep-t);
  margin-bottom: 10px;
}
.pep-toc-list { list-style: none; padding: 0; margin: 0; }
.pep-toc-list a {
  display: block;
  font-size: 12.5px;
  color: var(--text-tertiary);
  padding: 5px 0;
  line-height: 1.4;
  border-left: 2px solid transparent;
  padding-left: 8px;
  margin-left: -10px;
  transition: color 0.15s, border-color 0.15s;
}
.pep-toc-list a:hover { color: var(--text); border-left-color: var(--pep-bd-soft); }
.pep-toc-list a.is-active { color: var(--pep-t); border-left-color: var(--pep-bd); }

/* ============================================
   SECTION SHELL
   ============================================ */
.pep-section { padding: 56px 0; scroll-margin-top: 90px; }
.pep-section + .pep-section { padding-top: 30px; }
.pep-section-eyebrow {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px; font-weight: 600;
  letter-spacing: 0.16em; text-transform: uppercase;
  color: var(--pep-t); margin-bottom: 12px;
}
.pep-section-title {
  font-size: clamp(24px, 3.4vw, 32px);
  font-weight: 700; line-height: 1.15;
  color: var(--text); letter-spacing: -0.02em;
  margin-bottom: 10px;
}
.pep-section-sub {
  font-size: 15px; line-height: 1.7;
  color: var(--text-tertiary);
  max-width: 760px; margin-bottom: 22px;
}
.pep-section-sub strong { color: var(--text-secondary); }

/* ============================================
   CALLOUTS
   ============================================ */
.pep-callout {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-left: 3px solid var(--pep-bd-soft);
  border-radius: 10px;
  padding: 14px 18px;
  margin: 16px 0;
  font-size: 14px;
  line-height: 1.65;
  color: var(--text-secondary);
}
.pep-callout strong { color: var(--text); }
.pep-callout--info    { border-left-color: var(--pep-info-t);  background: linear-gradient(180deg, var(--pep-info-bg), transparent 90%), var(--bg-alt); }
.pep-callout--warn    { border-left-color: var(--pep-warn-t);  background: linear-gradient(180deg, var(--pep-warn-bg), transparent 90%), var(--bg-alt); }
.pep-callout--stop    { border-left-color: var(--pep-stop-t);  background: linear-gradient(180deg, var(--pep-stop-bg), transparent 90%), var(--bg-alt); }
.pep-callout-h {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10.5px; letter-spacing: 0.16em;
  text-transform: uppercase; font-weight: 700;
  color: var(--pep-t);
  margin-bottom: 6px;
  display: block;
}
.pep-callout--warn .pep-callout-h { color: var(--pep-warn-t); }
.pep-callout--stop .pep-callout-h { color: var(--pep-stop-t); }
.pep-callout--info .pep-callout-h { color: var(--pep-info-t); }

/* ============================================
   PEPTIDE-CHAIN DIAGRAM (CSS-only)
   ============================================ */
.pep-chain {
  display: flex;
  flex-wrap: wrap;
  gap: 12px;
  align-items: center;
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 12px;
  padding: 18px 20px;
  margin: 16px 0 0;
}
.pep-chain-step {
  display: flex; flex-direction: column;
  align-items: center; gap: 6px;
  flex: 1 1 130px;
  min-width: 130px;
}
.pep-chain-icon {
  display: flex; align-items: center; justify-content: center;
  gap: 4px;
  height: 44px;
}
.pep-chain-aa {
  width: 22px; height: 22px;
  border-radius: 50%;
  background: var(--pep-bg);
  border: 1.5px solid var(--pep-bd);
  display: inline-block;
}
.pep-chain-bond {
  width: 10px; height: 2px;
  background: var(--pep-bd-soft);
}
.pep-chain-fold {
  width: 38px; height: 26px;
  border: 2px solid var(--pep-bd);
  border-radius: 50% / 35%;
  background: linear-gradient(135deg, var(--pep-bg), transparent);
}
.pep-chain-label {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px; letter-spacing: 0.06em;
  color: var(--pep-t); font-weight: 700;
}
.pep-chain-sub {
  font-size: 11px; color: var(--text-tertiary);
  text-align: center; line-height: 1.4;
  max-width: 150px;
}
.pep-chain-arrow {
  color: var(--pep-bd); font-weight: 700;
  font-family: 'JetBrains Mono', monospace;
  font-size: 18px;
  flex: 0 0 auto;
}

/* ============================================
   UNIVERSE MAP — category cards
   ============================================ */
.pep-universe {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
  gap: 12px;
}
.pep-cat {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 12px;
  padding: 16px 18px;
  display: flex; flex-direction: column; gap: 8px;
  transition: border-color 0.16s, background 0.16s;
}
.pep-cat:hover { background: var(--surface); border-color: var(--pep-bd-soft); }
.pep-cat-head {
  display: flex; align-items: center; gap: 10px;
}
.pep-cat-h {
  font-size: 15px; font-weight: 700; color: var(--text);
  margin: 0; letter-spacing: -0.005em; line-height: 1.3;
}
.pep-cat-what {
  font-size: 13px; line-height: 1.6;
  color: var(--text-secondary); margin: 0;
}
.pep-cat-why {
  font-size: 12.5px; line-height: 1.6;
  color: var(--text-tertiary); margin: 0;
}
.pep-cat-why strong { color: var(--text-secondary); }
.pep-cat-examples {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px; color: var(--text-tertiary);
  line-height: 1.7;
  border-top: 1px solid var(--border-light);
  padding-top: 8px;
  margin-top: 2px;
}
.pep-cat-examples strong { color: var(--pep-t); font-weight: 700; margin-right: 6px; }

/* ============================================
   EVIDENCE BADGES
   ============================================ */
.pep-evi {
  display: inline-flex; align-items: center;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  font-weight: 700;
  padding: 3px 8px;
  border-radius: 4px;
  border: 1px solid var(--border-light);
  background: var(--tag-bg);
  color: var(--text-tertiary);
  white-space: nowrap;
}
.pep-evi--approved   { color: var(--pep-ok-t);   border-color: var(--pep-ok-bd);   background: var(--pep-ok-bg); }
.pep-evi--clinical   { color: var(--pep-info-t); border-color: var(--pep-info-bd); background: var(--pep-info-bg); }
.pep-evi--early      { color: #B0A4F0;           border-color: rgba(176,164,240,0.36); background: rgba(176,164,240,0.06); }
.pep-evi--preclinical{ color: var(--pep-warn-t); border-color: var(--pep-warn-bd); background: var(--pep-warn-bg); }
.pep-evi--theoretical{ color: var(--text-tertiary); border-color: var(--border); background: var(--bg); }
.pep-evi--grey       { color: var(--pep-stop-t); border-color: var(--pep-stop-bd); background: var(--pep-stop-bg); }
.pep-evi--banned     { color: var(--pep-stop-t); border-color: var(--pep-stop-bd); background: var(--pep-stop-bg); }
.pep-evi--cosmetic   { color: #E0B5DA;           border-color: rgba(224,181,218,0.36); background: rgba(224,181,218,0.06); }

/* badge legend */
.pep-evi-legend {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
  gap: 10px;
  margin-top: 14px;
}
.pep-evi-legend-row {
  display: grid;
  grid-template-columns: auto 1fr;
  align-items: center;
  gap: 12px;
  padding: 10px 12px;
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 8px;
}
.pep-evi-legend-d {
  font-size: 12px; line-height: 1.55;
  color: var(--text-tertiary);
}

/* ============================================
   PEPTIDE TABLE (responsive)
   ============================================ */
.pep-table-controls {
  display: flex; flex-wrap: wrap; gap: 10px;
  margin-bottom: 14px;
}
.pep-table-search {
  flex: 1 1 240px;
  min-width: 200px;
  padding: 10px 14px;
  font-size: 14px;
  color: var(--text);
  background: var(--bg-alt);
  border: 1px solid var(--border);
  border-radius: 8px;
  font-family: inherit;
}
.pep-table-search:focus { outline: 2px solid var(--pep-bd); outline-offset: 2px; }
.pep-table-select {
  padding: 9px 12px;
  font-size: 12.5px;
  color: var(--text);
  background: var(--bg-alt);
  border: 1px solid var(--border);
  border-radius: 8px;
  font-family: 'JetBrains Mono', monospace;
  cursor: pointer;
}
.pep-table-count {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11.5px;
  color: var(--text-tertiary);
  margin-bottom: 10px;
}

.pep-table-wrap {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 12px;
  overflow: hidden;
}
.pep-table {
  width: 100%;
  border-collapse: collapse;
  font-size: 13px;
}
.pep-table thead {
  background: rgba(63, 168, 140, 0.06);
}
.pep-table th {
  text-align: left;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  font-weight: 700;
  color: var(--pep-t);
  padding: 10px 12px;
  border-bottom: 1px solid var(--border-light);
}
.pep-table td {
  padding: 10px 12px;
  border-bottom: 1px solid var(--border-light);
  color: var(--text-secondary);
  line-height: 1.55;
  vertical-align: top;
}
.pep-table tr:last-child td { border-bottom: none; }
.pep-table tr.is-hidden { display: none; }
.pep-table-name {
  color: var(--text);
  font-weight: 600;
}
.pep-table-cat {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--pep-t);
}
.pep-table-note {
  font-size: 12px; color: var(--text-tertiary);
  line-height: 1.55;
}

/* Mobile collapse */
@media (max-width: 760px) {
  .pep-table thead { display: none; }
  .pep-table tr {
    display: block;
    padding: 12px 14px;
    border-bottom: 1px solid var(--border-light);
  }
  .pep-table td {
    display: block;
    padding: 4px 0;
    border-bottom: none;
  }
  .pep-table td::before {
    content: attr(data-label);
    font-family: 'JetBrains Mono', monospace;
    font-size: 9.5px;
    letter-spacing: 0.14em;
    text-transform: uppercase;
    color: var(--pep-t);
    font-weight: 700;
    display: block;
    margin-bottom: 2px;
  }
  .pep-table td.pep-table-name { font-size: 15px; padding-bottom: 6px; }
  .pep-table td.pep-table-name::before { display: none; }
}

/* ============================================
   BPC-157 EVIDENCE BOX
   ============================================ */
.pep-bpc {
  background: linear-gradient(180deg, var(--pep-stop-bg), transparent 80%), var(--bg-alt);
  border: 1px solid var(--pep-stop-bd);
  border-radius: 14px;
  padding: 22px 24px;
}
.pep-bpc-h {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px; letter-spacing: 0.16em;
  text-transform: uppercase; font-weight: 700;
  color: var(--pep-stop-t);
  margin-bottom: 12px;
}
.pep-bpc-row {
  display: grid;
  grid-template-columns: 1fr 1.5fr 1fr;
  gap: 14px;
  padding: 10px 0;
  border-bottom: 1px solid var(--border-light);
  font-size: 13px;
  line-height: 1.6;
  color: var(--text-secondary);
}
.pep-bpc-row:last-child { border-bottom: none; }
.pep-bpc-row--head {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  color: var(--pep-t);
  font-weight: 700;
}
.pep-bpc-claim { color: var(--text); font-weight: 600; }
@media (max-width: 720px) {
  .pep-bpc-row { grid-template-columns: 1fr; gap: 4px; padding: 10px 0; }
  .pep-bpc-row--head { display: none; }
  .pep-bpc-row > div::before {
    content: attr(data-col);
    font-family: 'JetBrains Mono', monospace;
    font-size: 9.5px; letter-spacing: 0.14em;
    text-transform: uppercase;
    color: var(--pep-t); font-weight: 700;
    display: block; margin-bottom: 2px;
  }
}

/* ============================================
   APPROVED MEDICINES — grouped table
   ============================================ */
.pep-approved {
  display: grid;
  grid-template-columns: 1fr;
  gap: 10px;
}
.pep-approved-group {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-left: 3px solid var(--pep-bd-soft);
  border-radius: 12px;
  padding: 14px 16px;
}
.pep-approved-h {
  font-size: 15px; font-weight: 700;
  color: var(--text);
  margin: 0 0 4px;
  letter-spacing: -0.005em;
}
.pep-approved-sub {
  font-size: 12.5px;
  color: var(--text-tertiary);
  margin-bottom: 8px;
}
.pep-approved-list {
  display: flex; flex-wrap: wrap; gap: 6px;
}
.pep-approved-pill {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11.5px;
  background: var(--bg);
  border: 1px solid var(--pep-bd-faint);
  border-radius: 999px;
  padding: 4px 12px;
  color: var(--pep-t);
}

/* ============================================
   CHALLENGE / ENGINEERING LISTS
   ============================================ */
.pep-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(240px, 1fr));
  gap: 10px;
}
.pep-grid-card {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 10px;
  padding: 12px 14px;
}
.pep-grid-h {
  font-size: 13.5px; font-weight: 700;
  color: var(--text);
  margin: 0 0 4px;
  letter-spacing: -0.005em;
}
.pep-grid-d {
  font-size: 12px; line-height: 1.6;
  color: var(--text-tertiary);
  margin: 0;
}

/* ============================================
   DATABASE CARDS
   ============================================ */
.pep-databases {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
  gap: 10px;
}
.pep-db {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 12px;
  padding: 16px 18px;
  display: flex; flex-direction: column; gap: 6px;
}
.pep-db-name {
  font-size: 15px; font-weight: 700;
  color: var(--text);
  margin: 0;
  letter-spacing: -0.005em;
}
.pep-db-what {
  font-size: 12.5px; line-height: 1.6;
  color: var(--text-secondary); margin: 0;
}
.pep-db-best {
  font-size: 11.5px; line-height: 1.55;
  color: var(--text-tertiary); margin: 0;
}
.pep-db-best strong { color: var(--pep-t); font-weight: 700; }
.pep-db-link {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--pep-t);
  margin-top: auto;
  padding-top: 6px;
  border-top: 1px solid var(--border-light);
  word-break: break-all;
}
.pep-db-link a { color: inherit; }
.pep-db-link a:hover { color: var(--pep-t-soft); border-bottom: 1px solid var(--pep-bd-soft); }

/* ============================================
   FAQ ACCORDION
   ============================================ */
.pep-faq { display: grid; grid-template-columns: 1fr; gap: 6px; }
.pep-faq-item {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 10px;
  overflow: hidden;
}
.pep-faq-item[open] { border-color: var(--pep-bd-soft); }
.pep-faq-summary {
  list-style: none;
  display: flex; align-items: center; gap: 10px;
  padding: 14px 18px;
  cursor: pointer;
  font-size: 14.5px;
  font-weight: 600;
  color: var(--text);
}
.pep-faq-summary::-webkit-details-marker { display: none; }
.pep-faq-summary::after {
  content: '+';
  margin-left: auto;
  font-family: 'JetBrains Mono', monospace;
  font-size: 18px;
  color: var(--pep-t);
  transition: transform 0.18s ease;
}
.pep-faq-item[open] .pep-faq-summary::after { content: '–'; }
.pep-faq-body {
  padding: 0 18px 16px;
  font-size: 13.5px;
  line-height: 1.7;
  color: var(--text-secondary);
}
.pep-faq-body p { margin: 0 0 8px; }
.pep-faq-body p:last-child { margin: 0; }

/* ============================================
   GLOSSARY
   ============================================ */
.pep-glossary {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
  gap: 10px;
}
.pep-glossary-term {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 10px;
  padding: 12px 14px;
}
.pep-glossary-name {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--pep-t);
  font-weight: 700;
  margin-bottom: 4px;
}
.pep-glossary-d {
  font-size: 13px; line-height: 1.6;
  color: var(--text-secondary); margin: 0;
}

/* ============================================
   SOURCES
   ============================================ */
.pep-sources {
  background: var(--bg-alt);
  border: 1px solid var(--border-light);
  border-radius: 12px;
  padding: 20px 22px;
}
.pep-sources-h {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  color: var(--pep-t);
  font-weight: 700;
  margin-bottom: 10px;
}
.pep-sources-list {
  list-style: none; padding: 0; margin: 0;
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
  gap: 6px;
}
.pep-sources-list li {
  font-size: 13px; line-height: 1.65;
  color: var(--text-secondary);
  padding-left: 14px;
  position: relative;
}
.pep-sources-list li::before {
  content: '·';
  position: absolute; left: 0;
  color: var(--pep-t);
  font-weight: 700;
}
.pep-sources-list li a { color: inherit; }
.pep-sources-list li a:hover { color: var(--pep-t); border-bottom: 1px solid var(--pep-bd-soft); }

/* ============================================
   FINAL DISCLAIMER
   ============================================ */
.pep-final {
  background: linear-gradient(180deg, var(--pep-stop-bg), transparent 90%), var(--bg-alt);
  border: 1px solid var(--pep-stop-bd);
  border-radius: 14px;
  padding: 24px 26px;
  margin-top: 30px;
}
.pep-final-h {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  color: var(--pep-stop-t);
  font-weight: 700;
  margin-bottom: 12px;
}
.pep-final-d {
  font-size: 14px; line-height: 1.7;
  color: var(--text-secondary);
  margin: 0;
}

/* ============================================
   MOBILE
   ============================================ */
@media (max-width: 720px) {
  .pep-hero { padding: 130px 0 40px; }
  .pep-section { padding: 36px 0; }
  .pep-cat { padding: 14px 16px; }
  .pep-bpc { padding: 16px 18px; }
  .pep-final { padding: 20px 22px; }
}

@media (max-width: 480px) {
  .pep-hero-title { font-size: 32px; }
  .pep-hero-subtitle { font-size: 15.5px; }
  .pep-hero-stats { grid-template-columns: 1fr 1fr; }
}

@media (prefers-reduced-motion: reduce) {
  .pep-cat, .pep-toc-list a, .pep-faq-summary::after { transition: none !important; }
}